Postnatal conversion of methylcytosine to hydroxymethylcytosine reconfigures the human neuronal epigenome
Heng Xu, Jo-fan Chien, Alexey Kozlenkov, Ramu Vadukapuram, Junhao Li, Yu Wei, Andrew J. Dwork, Chunyu Liu, Stella Dracheva, and Eran Mukamel.
BioRxiv (2026) doi.org/10.64898/2026.02.18.706675
Supported by
PsychENCODE
/NIH grants R01-MH122590, R01-MH122591 and R01-MH122592
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Individual donors
Glu
MGE-GABA
mCG and hmCG (overlaid)
DNA total methylation (5mCG+5hmCG, BS)
DNA methylation (5mCG, OxBS)
DNA hydroxymethylation (5hmCG, BS-OXBS)
H3K27ac (active enhancer/promoter)
H3K9me3 (heterochromatin)
H3K27me3 (PRC2, polycomb repression)
RNA
Age DMR (5mCG+5hmCG, BS)
H3K27ac Peaks
H3K9me3 Peaks
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Age differential H3K27ac Peaks
Age differential H3K9me3 Peaks
Age differential H3K27me3 Peaks
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BCL11A
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CLOCK
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DEAF1
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NEUROD1
NFIB
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NRF1
PKNOX1
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PRDM15
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SKIL
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SP4
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