Postnatal conversion of methylcytosine to hydroxymethylcytosine reconfigures the human neuronal epigenome
Heng Xu, Jo-fan Chien, Alexey Kozlenkov, Chunyu Liu, Stella Dracheva, and Eran Mukamel.
BioRxiv (2026) doi.org/10.64898/2026.02.18.706675
Supported by
PsychENCODE
/NIH grants R01-MH122590, R01-MH122591 and R01-MH122592
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Merged by age group
Individual donors
Glu
MGE-GABA
mCG and hmCG (overlaid)
DNA total methylation (5mCG+5hmCG, BS)
DNA methylation (5mCG, OxBS)
DNA hydroxymethylation (5hmCG, BS-OXBS)
H3K27ac (active enhancer/promoter)
H3K9me3 (heterochromatin)
H3K27me3 (PRC2, polycomb repression)
RNA
Age DMR (5mCG+5hmCG, BS)
H3K27ac Peaks
H3K9me3 Peaks
H3K27me3 Peaks
Age differential H3K27ac Peaks
Age differential H3K9me3 Peaks
Age differential H3K27me3 Peaks
Infancy
Early_Childhood
Late_Childhood
Adolescence
Early_Adulthood
Adulthood
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Celltype
Modality
TF ChIP Annotation
ASCL1
ASH1L
ASH2L
BCL11A
BCL11B
BHLHE40
BHLHE41
BMI1
BRD4
CHD4
CLOCK
CREB
CREM
CTCF
DEAF1
E2F-1
EGR1
EWSR1
GABPB1
GMEB1
HCFC1
KAT2B
KLF16
KLF5
MAZ
MEIS2
MITF
MYT1L
NEUROD1
NFIB
NFIC
NR2F1
NR3C1
NRF1
PKNOX1
POU3F2
PRDM15
Pol2
RELB
SATB2
SIN3A
SKIL
SMARCA5
SMC3
SP1
SP4
SREBP2
SRF
STAT4
TARDBP
TBR1
TCF12
TRIM28
YY1
ZEB1
ZEB2
ZFP91
ZHX1
ZNF143
ZNF24
ZNF384